Friday, May 20, 2011

US Man Walk Again Signalling A Cure For The Disabled?

Paralysed man can stand and move his legs again
Mr Summers: ''The moment I stood up, I was in disbelief''
A US man who was paralysed from the chest down after being hit by a car is now able to stand with electrical stimulation of his spinal cord.
Rob Summers, from Oregon, said standing on his own was "the most amazing feeling".

He can voluntarily move his toes, hips, knees and ankles and also walk on a treadmill while being supported, according to research in the Lancet.

However, a UK expert said this should not be interpreted as a cure.
Rob Summers Rob Summers is able to stand while his spinal cord is stimulated
Rob was a keen baseball player and in 2006 was part of the team which won the College World Series.
But in that summer he was injured in a hit and run accident and his spinal cord was damaged.

Messages from the brain, which used to travel down the spinal cord, were blocked and he was paralysed.

Doctors surgically implanted 16 electrodes into his spine.
Rob trained daily in trying to stand, walk and move his legs, while electrical pulses were sent to the spinal cord.

Within days he was able to stand independently and eventually he could control his legs and step, with assistance, for short periods of time.

"None of us believed it," said Professor Reggie Edgerton, from the University of California. "I was afraid to believe it."
How does it work? In most spinal cord injuries only a small amount of the tissue is damaged so many nerve cells remain.
The researchers say these cells pick up signals from the legs and respond automatically. This is what allows a healthy person to stand still or walk without actively thinking about it and it is this process the doctors were trying to tap into.

But after a spinal injury the cells need help, in this case precise electric stimulation.

It mimics a message from the brain to start moving and changes the "mood" of the spinal cord so that it is able to hear the information which is coming in from the legs and respond. Researchers say this, coupled with intensive training, allowed Rob to stand or walk while supported on a treamill.

The researchers admit to having "no idea" about how the brain was also able to gain direct control of the toes, knee and hips.

They speculate that some nerve cells are being reactivated or maybe more of them are being created allowed signals from the brain to pass down the spinal cord.

Rob has also regained other functions such as bladder, bowel and blood pressure control.

He said it had been a "long journey of countless hours of training" which had "completely changed my life".

He added: "For someone who for four years was unable to even move a toe, to have the freedom and ability to stand on my own is the most amazing feeling."
This study has proved that electrical stimulation works in one person. Four more patients are being lined up to further test the treatment.

Professor Geoffrey Raisman, from the Institute of Neurology at UCL, said: "This one case is interesting, and from one of the leading groups in the world. To what extent this procedure could in the future provide a further and sustained improvement cannot be judged on the basis of one patient.

"From the point of view of people currently suffering from spinal cord injury, future trials of this procedure could add one more approach to getting some benefit. It is not and does not claim to be a cure."

Dr Melissa Andrews, from the Cambridge Centre for Brain Repair, said that while the study was a "little bit mind blowing" people should not say this is a cure.

She added: "I think people need to read this and say the possibility is out there, but it may not come tomorrow. It's the closest we've ever seen and it's the best hope right now."

Professor Susan Harkema, who was part of the study at the University of Louisville, said: "It is really critical to be clear that it's still in a research realm, but stay tuned we're going to learn a lot more every day."

For Rob he sees his story as a message of hope to people who are paralysed and as for walking again: "I see it as a major possibility."

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